Cystathionine gamma-lyase
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| cystathionine gamma-lyase | |||||||||
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 Cysteine metabolism. Cystathionase catalyzes the lower reaction. |
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| Identifiers | |||||||||
| EC number | 4.4.1.1 | ||||||||
| CAS number | 9012-96-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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Cystathionine gamma-lyase (or cystathionase) is an enzyme which breaks down cystathionine into cysteine and α-ketobutyrate. Pyridoxal phosphate is a prosthetic group of this enzyme.
Cystathionine gamma-lyase also catalyses the following elimination reactions:
- L-homoserine to form H2O, NH3 and 2-oxobutanoate
- L-cystine, producing thiocysteine, pyruvate and NH3
- L-cysteine producing pyruvate, NH3 and H2S
In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide.[1]
Contents |
Examples [edit]
The following cystathionine gamma-lyase is expressed in humans:
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Pathology [edit]
An deficiency is associated with cystathioninuria.
See also [edit]
External links [edit]
- Cystathionine gamma-lyase at the US National Library of Medicine Medical Subject Headings (MeSH)
References [edit]
- ^ Wang R (March 2010). "Toxic Gas, Lifesaver". Scientific American: 52.
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