Cysteine dioxygenase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cysteine dioxygenase
Identifiers
EC number 1.13.11.20
CAS number 37256-59-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
cysteine dioxygenase, type I
Identifiers
Symbol CDO1
Entrez 1036
HUGO 1795
OMIM 603943
RefSeq NM_001801
UniProt Q16878
Other data
Locus Chr. 5 q23.2

Cysteine dioxygenase (CDO, CAS number: 37256-59-0) is a mammalian non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.

CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation

Cysteine sulfinic acid lies at a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.

References[edit]

  • Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I (February 1976). "Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)". Biochim. Biophys. Acta 422 (2): 273–9. doi:10.1016/0005-2744(76)90138-8. PMID 2307. 

External links[edit]