Cysteine dioxygenase (CDO, CAS number: 37256-59-0) is a mammalian non- heme iron enzyme that catalyzes the conversion of L- cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.
CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation
Cysteine sulfinic acid lies at a branch-point in
cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine ( 2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.
References [ edit ]
Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I (February 1976). "Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)". Biochim. Biophys. Acta 422 (2): 273–9. doi: 10.1016/0005-2744(76)90138-8. PMID 2307.
External links [ edit ]