Cysteinyl leukotriene receptor 1

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Cysteinyl leukotriene receptor 1
Identifiers
Symbols CYSLTR1 ; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81
External IDs OMIM300201 MGI1926218 HomoloGene4837 IUPHAR: CysLT1 ChEMBL: 1798 GeneCards: CYSLTR1 Gene
Orthologs
Species Human Mouse
Entrez 10800 58861
Ensembl ENSG00000173198 ENSMUSG00000052821
UniProt Q9Y271 Q99JA4
RefSeq (mRNA) NM_006639 NM_021476
RefSeq (protein) NP_006630 NP_067451
Location (UCSC) Chr X:
77.53 – 77.58 Mb
Chr X:
106.57 – 106.6 Mb
PubMed search [1] [2]

Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system.[4] Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.[3]

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References[edit]

  1. ^ Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (Jul 1999). "Characterization of the human cysteinyl leukotriene CysLT1 receptor". Nature 399 (6738): 789–93. doi:10.1038/21658. PMID 10391245. 
  2. ^ Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW (Sep 1999). "Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor". Mol Pharmacol 56 (3): 657–63. PMID 10462554. 
  3. ^ a b "Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1". 
  4. ^ . UniProt Consortium http://www.uniprot.org/uniprot/Q9Y271.  Missing or empty |title= (help)

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.