Cysteinyl leukotriene receptor 2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cysteinyl leukotriene receptor 2
Symbols CYSLTR2 ; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; hGPCR21
External IDs OMIM605666 MGI1917336 HomoloGene10688 IUPHAR: 270 ChEMBL: 4330 GeneCards: CYSLTR2 Gene
RNA expression pattern
PBB GE CYSLTR2 220813 at tn.png
More reference expression data
Species Human Mouse
Entrez 57105 70086
Ensembl ENSG00000152207 ENSMUSG00000033470
UniProt Q9NS75 Q920A1
RefSeq (mRNA) NM_020377 NM_001162412
RefSeq (protein) NP_065110 NP_001155884
Location (UCSC) Chr 13:
49.28 – 49.28 Mb
Chr 14:
73.03 – 73.05 Mb
PubMed search [1] [2]

Cysteinyl leukotriene receptor 2 is a protein that in humans is encoded by the CYSLTR2 gene.[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1.[citation needed] This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems.[3]

See also[edit]


  1. ^ Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (Aug 2000). "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor". Biochem Biophys Res Commun 274 (2): 316–22. doi:10.1006/bbrc.2000.3140. PMID 10913337. 
  2. ^ Van Keer C, Kersters K, De Ley J (Sep 1976). "L-Sorbose metabolism in Agrobacterium tumefaciens". Antonie Van Leeuwenhoek 42 (1–2): 13–24. doi:10.1007/BF00399445. PMID 1085123. 
  3. ^ a b "Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.