Cysteinyl leukotriene receptor 2

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Cysteinyl leukotriene receptor 2
Identifiers
Symbols CYSLTR2 ; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; hGPCR21
External IDs OMIM605666 MGI1917336 HomoloGene10688 IUPHAR: CysLT2 ChEMBL: 4330 GeneCards: CYSLTR2 Gene
RNA expression pattern
PBB GE CYSLTR2 220813 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57105 70086
Ensembl ENSG00000152207 ENSMUSG00000033470
UniProt Q9NS75 Q920A1
RefSeq (mRNA) NM_020377 NM_001162412
RefSeq (protein) NP_065110 NP_001155884
Location (UCSC) Chr 13:
49.28 – 49.28 Mb
Chr 14:
73.03 – 73.05 Mb
PubMed search [1] [2]

Cysteinyl leukotriene receptor 2 is a protein that in humans is encoded by the CYSLTR2 gene.[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1.[citation needed] This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems.[3]

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References[edit]

  1. ^ Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (Aug 2000). "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor". Biochem Biophys Res Commun 274 (2): 316–22. doi:10.1006/bbrc.2000.3140. PMID 10913337. 
  2. ^ Van Keer C, Kersters K, De Ley J (Sep 1976). "L-Sorbose metabolism in Agrobacterium tumefaciens". Antonie Van Leeuwenhoek 42 (1–2): 13–24. doi:10.1007/BF00399445. PMID 1085123. 
  3. ^ a b "Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2". 

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Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.