Cystic nephroma

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Cystic nephroma
Classification and external resources
Cystic nephroma low mag.jpg
Micrograph of a cystic nephroma (left of image). Normal kidney is seen on the right. H&E stain.
ICD-10 D30.0
ICD-9 223.0

A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST) and renal epithelial stromal tumour (REST),[1] is a type of rare benign kidney tumour.

Symptoms[edit]

Cystic nephromas are often asymptomatic. They are typically discovered on medical imaging incidentally (i.e. an incidentaloma).

Diagnosis[edit]

Cystic nephromas are diagnosed by biopsy or excision. It is important to correctly diagnose them as, radiologically, they may mimic the appearance of a renal cell carcinoma that is cystic.[2]

Pathologic diagnosis[edit]

High magnification micrograph of a cystic nephroma showing the characteristic simple epithelium with hobnail morphology, and the ovarian-like stroma. H&E stain.

The characteristics of cystic nephromas are:

  • Cysts lined by a simple epithelium with a hobnail morphology, i.e. the nuclei of the cyst lining epithelium bulges into the lumen of the cysts,
  • Ovarian-like stroma that has a:

Cystic nephromas have an immunostaining pattern like ovarian stroma; they are positive for:

Differential diagnosis[edit]

Additional images[edit]

References[edit]

  1. ^ Turbiner J, Amin MB, Humphrey PA, et al. (April 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term". Am. J. Surg. Pathol. 31 (4): 489–500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095. 
  2. ^ Small JE et al. Cystic Nephroma. BrighamRAD Teaching Case Database. URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/385/full.html. Accessed: July 25, 2009.