Cytochalasin D

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Cytochalasin D
Cytochalasin D.png
Identifiers
CAS number 22144-77-0 YesY
PubChem 5458428
ChemSpider 16736231 YesY
ChEBI CHEBI:529996 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C30H37NO6
Molar mass 507.62 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Cytochalasin D is a member of the class of mycotoxins known as cytochalasins. Cytochalasin D is an alkaloid produced by Helminthosporium and other molds.

Cytochalasin D is a cell-permeable and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It is believed to bind to F-actin polymer and prevent polymerization of actin monomers. [1]

References[edit]

  1. ^ Heptinstall, J. A. May H. Ratan J. R. Glenn W. L (1998). "GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly.". Platelets 9 (3): 227–32. doi:10.1080/09537109876744. PMID 16793707. 

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