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PBB Protein CYGB image.jpg
PDB rendering based on 1umo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CYGB ; HGB; STAP
External IDs OMIM608759 MGI2149481 HomoloGene12706 GeneCards: CYGB Gene
RNA expression pattern
PBB GE CYGB gnf1h08384 at tn.png
More reference expression data
Species Human Mouse
Entrez 114757 114886
Ensembl ENSG00000161544 ENSMUSG00000020810
UniProt Q8WWM9 Q9CX80
RefSeq (mRNA) NM_134268 NM_030206
RefSeq (protein) NP_599030 NP_084482
Location (UCSC) Chr 17:
74.52 – 74.55 Mb
Chr 11:
116.65 – 116.65 Mb
PubMed search [1] [2]

Cytoglobin is the protein product of CYGB, a human and mammalian gene.[1]

Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It is thought to protect against hypoxia. The predicted function of cytoglobin is the transfer of oxygen from arterial blood to the brain.[2]

Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002).[supplied by OMIM][1]


CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver.[3]


  1. ^ a b "Entrez Gene: CYGB cytoglobin". 
  2. ^ "Why Diving Marine Mammals Resist Brain Damage from Low Oxygen". 
  3. ^ Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N (2014). "Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver". Lab. Invest. 94 (2): 192–207. doi:10.1038/labinvest.2013.135. PMID 24296877. 

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