For example, a gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection. Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury. Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue) and bismuth chelate (tri-potassium di-citrato bismuthate).
- "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine.
- Tulassay Z, Herszényi L (April 2010). "Gastric mucosal defense and cytoprotection". Best Pract Res Clin Gastroenterol 24 (2): 99–108. doi:10.1016/j.bpg.2010.02.006. PMID 20227024.
- Wallace JL (September 1992). "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterol. Clin. North Am. 21 (3): 631–41. PMID 1516961.
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