Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
Cell motility, adhesion, and cytokinesis, and other functions of the cell cortex are mediated by the reorganization of the actincytoskeleton and recent evidence suggests a role for formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPaseRho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res.5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID9734811.
Aspenström P, Richnau N, Johansson AS (2006). "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.". Exp. Cell Res.312 (12): 2180–94. doi:10.1016/j.yexcr.2006.03.013. PMID16630611.
Sato A, Khadka DK, Liu W, et al. (2007). "Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation.". Development133 (21): 4219–31. doi:10.1242/dev.02590. PMID17021034.