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Dishevelled associated activator of morphogenesis 1
Protein DAAM1 PDB 2j1d.png
PDB rendering based on 2j1d.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DAAM1 ; FLJ41657; KIAA0666
External IDs OMIM606626 MGI1914596 HomoloGene36635 GeneCards: DAAM1 Gene
RNA expression pattern
PBB GE DAAM1 216060 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23002 208846
Ensembl ENSG00000100592 ENSMUSG00000034574
UniProt Q9Y4D1 Q8BPM0
RefSeq (mRNA) NM_001270520 NM_001286452
RefSeq (protein) NP_001257449 NP_001273381
Location (UCSC) Chr 14:
59.66 – 59.84 Mb
Chr 12:
71.83 – 71.99 Mb
PubMed search [1] [2]

Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene.[1][2][3] Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.


Cell motility, adhesion, and cytokinesis, and other functions of the cell cortex are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.[3]

Clinical significance[edit]

The deletion of a single copy of this gene has been associated with congenital heart defects.[4]


  1. ^ Habas R, Kato Y, He X (Jan 2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". Cell 107 (7): 843–54. doi:10.1016/S0092-8674(01)00614-6. PMID 11779461. 
  2. ^ Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels LW, Habas R (Jan 2008). "Mechanism of activation of the Formin protein Daam1". Proc Natl Acad Sci U S A 105 (1): 210–5. doi:10.1073/pnas.0707277105. PMC 2224188. PMID 18162551. 
  3. ^ a b "Entrez Gene: DAAM1 dishevelled associated activator of morphogenesis 1". 
  4. ^ Bao B, Zhang L, Hu H, Yin S, Liang Z (August 2012). "Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report". BMC Med. Genet. 13 (1): 63. doi:10.1186/1471-2350-13-63. PMC 3482563. PMID 22857009. 

Further reading[edit]