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Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Protein DAB2 PDB 1m7e.png
PDB rendering based on 1m7e.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DAB2 ; DOC-2; DOC2
External IDs OMIM601236 MGI109175 HomoloGene1026 GeneCards: DAB2 Gene
RNA expression pattern
PBB GE DAB2 201278 at tn.png
PBB GE DAB2 201279 s at tn.png
PBB GE DAB2 201280 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1601 13132
Ensembl ENSG00000153071 ENSMUSG00000022150
UniProt P98082 P98078
RefSeq (mRNA) NM_001244871 NM_001008702
RefSeq (protein) NP_001231800 NP_001008702
Location (UCSC) Chr 5:
39.37 – 39.46 Mb
Chr 15:
6.3 – 6.44 Mb
PubMed search [1] [2]

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.[1][2]

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).[3]


DAB2 has been shown to interact with C-src tyrosine kinase,[4] Cdk1,[5] Src,[4] LRP2,[6] DVL3,[7] PIN1,[5] MYO6,[8][9] DVL2,[7] DAB2IP,[10] Mothers against decapentaplegic homolog 3[11] and Mothers against decapentaplegic homolog 2.[11]


  1. ^ Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R (January 1997). "Sequence, genomic structure, and chromosomal assignment of human DOC-2". Genomics 33 (2): 207–13. doi:10.1006/geno.1996.0185. PMID 8660969. 
  2. ^ Mok SC, Chan WY, Wong KK, Cheung KK, Lau CC, Ng SW, Baldini A, Colitti CV, Rock CO, Berkowitz RS (June 1998). "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer". Oncogene 16 (18): 2381–7. doi:10.1038/sj.onc.1201769. PMID 9620555. 
  3. ^ "Entrez Gene: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)". 
  4. ^ a b Zhou, Jian; Scholes Jessica; Hsieh Jer-Tsong (February 2003). "Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer". J. Biol. Chem. (United States) 278 (9): 6936–41. doi:10.1074/jbc.M210628200. ISSN 0021-9258. PMID 12473651. 
  5. ^ a b He, Junqi; Xu Jianguo; Xu Xiang-Xi; Hall Randy A (July 2003). "Cell cycle-dependent phosphorylation of Disabled-2 by cdc2". Oncogene (England) 22 (29): 4524–30. doi:10.1038/sj.onc.1206767. ISSN 0950-9232. PMID 12881709. 
  6. ^ Oleinikov, A V; Zhao J; Makker S P (May 2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin". Biochem. J. (ENGLAND). 347 Pt 3 (3): 613–21. doi:10.1042/0264-6021:3470613. ISSN 0264-6021. PMC 1220996. PMID 10769163. 
  7. ^ a b Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. (England) 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222. 
  8. ^ Morris, Shelli M; Arden Susan D, Roberts Rhys C, Kendrick-Jones John, Cooper Jonathan A, Luzio J Paul, Buss Folma (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic (Denmark) 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. ISSN 1398-9219. PMID 11967127. 
  9. ^ Inoue, Akira; Sato Osamu; Homma Kazuaki; Ikebe Mitsuo (March 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. (United States) 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. ISSN 0006-291X. PMID 11906161. 
  10. ^ Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone Nora; Hsieh Jer-Tsong (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. (United States) 277 (15): 12622–31. doi:10.1074/jbc.M110568200. ISSN 0021-9258. PMID 11812785. 
  11. ^ a b Hocevar, B A; Smine A; Xu X X; Howe P H (June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway". EMBO J. (England) 20 (11): 2789–801. doi:10.1093/emboj/20.11.2789. ISSN 0261-4189. PMC 125498. PMID 11387212. 

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