DAB2IP

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DAB2 interacting protein
Identifiers
Symbols DAB2IP ; AF9Q34; AIP-1; AIP1; DIP1/2
External IDs OMIM609205 MGI1916851 HomoloGene13058 GeneCards: DAB2IP Gene
Orthologs
Species Human Mouse
Entrez 153090 69601
Ensembl ENSG00000136848 ENSMUSG00000026883
UniProt Q5VWQ8 Q3UHC7
RefSeq (mRNA) NM_032552 NM_001001602
RefSeq (protein) NP_115941 NP_001001602
Location (UCSC) Chr 9:
124.33 – 124.55 Mb
Chr 2:
35.56 – 35.73 Mb
PubMed search [1] [2]

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.[1][2][3]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM][3]

Interactions[edit]

DAB2IP has been shown to interact with DAB2.[4]

References[edit]

  1. ^ Chen H, Pong RC, Wang Z, Hsieh JT (April 2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization". Genomics 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990. 
  2. ^ Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785. 
  3. ^ a b "Entrez Gene: DAB2IP DAB2 interacting protein". 
  4. ^ Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone Nora; Hsieh Jer-Tsong (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. (United States) 277 (15): 12622–31. doi:10.1074/jbc.M110568200. ISSN 0021-9258. PMID 11812785. 

Further reading[edit]