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Dachshund family transcription factor 1
Protein DACH1 PDB 1l8r.png
PDB rendering based on 1l8r.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DACH1 ; DACH
External IDs OMIM603803 MGI1277991 HomoloGene7288 GeneCards: DACH1 Gene
RNA expression pattern
PBB GE DACH1 205471 s at tn.png
PBB GE DACH1 205472 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1602 13134
Ensembl ENSG00000165659 ENSMUSG00000055639
UniProt Q9UI36 Q9QYB2
RefSeq (mRNA) NM_004392 NM_001038610
RefSeq (protein) NP_004383 NP_001033699
Location (UCSC) Chr 13:
72.01 – 72.44 Mb
Chr 14:
97.79 – 98.17 Mb
PubMed search [1] [2]

Dachshund homolog 1 (Drosophila), also known as DACH1, is a protein which in humans is encoded by the DACH1 gene.[1][2][3]


This gene is similar to the D. melanogaster dachshund gene, which encodes a nuclear factor essential for determining cell fates in the eye, leg, and nervous system of the fly. It is a member of the Ski gene family and is thought to be involved in eye development. Four alternatively spliced transcripts encoding different isoforms have been described for this gene.[3]


DACH1 has been shown to interact with UBE2I.[4][5]


  1. ^ Hammond KL, Lettice LA, Hill RE, Lee M, Boyle S, Hanson IM (January 1999). "Human (DACH) and mouse (Dach) homologues of Drosophila dachshund map to chromosomes 13q22 and 14E3, respectively". Genomics 55 (2): 252–253. doi:10.1006/geno.1998.5662. PMID 9933575. 
  2. ^ Kozmik Z, Cvekl A (July 1999). "Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21". Genomics 59 (1): 110–111. doi:10.1006/geno.1999.5797. PMID 10395809. 
  3. ^ a b "Entrez Gene: DACH1 dachshund homolog 1 (Drosophila)". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Machon, O; Backman M; Julin K; Krauss S (October 2000). "Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac". Mech. Dev. (IRELAND) 97 (1–2): 3–12. doi:10.1016/S0925-4773(00)00402-0. ISSN 0925-4773. PMID 11025202. 

Further reading[edit]