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Defender against cell death 1
Symbols DAD1 ; OST2
External IDs OMIM600243 MGI101912 HomoloGene1027 GeneCards: DAD1 Gene
EC number
RNA expression pattern
PBB GE DAD1 200047 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1603 13135
Ensembl ENSG00000129562 ENSMUSG00000022174
UniProt P61803 P61804
RefSeq (mRNA) NM_001344 NM_001113358
RefSeq (protein) NP_001335 NP_001106829
Location (UCSC) Chr 14:
23.03 – 23.06 Mb
Chr 14:
54.24 – 54.25 Mb
PubMed search [1] [2]

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1 is an enzyme that in humans is encoded by the DAD1 gene.[1]

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.[1]


DAD1 has been shown to interact with MCL1.[2]


  1. ^ a b "Entrez Gene: DAD1 defender against cell death 1". 
  2. ^ Makishima, T; Yoshimi M; Komiyama S; Hara N; Nishimoto T (September 2000). "A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family". J. Biochem. (JAPAN) 128 (3): 399–405. doi:10.1093/oxfordjournals.jbchem.a022767. ISSN 0021-924X. PMID 10965038. 

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