DAP3

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Death associated protein 3
Identifiers
Symbols DAP3 ; DAP-3; MRP-S29; MRPS29; bMRP-10
External IDs OMIM602074 MGI1929538 HomoloGene3404 GeneCards: DAP3 Gene
RNA expression pattern
PBB GE DAP3 208822 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7818 65111
Ensembl ENSG00000132676 ENSMUSG00000068921
UniProt P51398 Q9ER88
RefSeq (mRNA) NM_001199849 NM_001164533
RefSeq (protein) NP_001186778 NP_001158005
Location (UCSC) Chr 1:
155.66 – 155.71 Mb
Chr 3:
88.92 – 88.95 Mb
PubMed search [1] [2]

28S ribosomal protein S29, mitochondrial is a protein that in humans is encoded by the DAP3 gene.[1][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5' UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.[3]

Interactions[edit]

DAP3 has been shown to interact with FADD,[4] TNFRSF10A,[4] Glucocorticoid receptor[5] and Heat shock protein 90kDa alpha (cytosolic), member A1.[5]

References[edit]

  1. ^ Kissil JL, Deiss LP, Bayewitch M, Raveh T, Khaspekov G, Kimchi A (January 1996). "Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death". J Biol Chem 270 (46): 27932–6. doi:10.1074/jbc.270.46.27932. PMID 7499268. 
  2. ^ Kissil JL, Kimchi A (September 1997). "Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization". Cytogenet Cell Genet 77 (3–4): 252. doi:10.1159/000134587. PMID 9284927. 
  3. ^ a b "Entrez Gene: DAP3 death associated protein 3". 
  4. ^ a b Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. (United States) 2 (6): 493–500. doi:10.1038/88684. ISSN 1529-2908. PMID 11376335. 
  5. ^ a b Hulkko, S M; Wakui H; Zilliacus J (August 2000). "The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function". Biochem. J. (ENGLAND). 349 Pt 3 (Pt 3): 885–93. ISSN 0264-6021. PMC 1221218. PMID 10903152. 

Further reading[edit]