DAPK1

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Death-associated protein kinase 1
Protein DAPK1 PDB 1ig1.png
PDB rendering based on 1ig1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DAPK1 ; DAPK
External IDs OMIM600831 MGI1916885 HomoloGene3626 ChEMBL: 2558 GeneCards: DAPK1 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE DAPK1 203139 at tn.png
PBB GE DAPK1 211214 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1612 69635
Ensembl ENSG00000196730 ENSMUSG00000021559
UniProt P53355 Q80YE7
RefSeq (mRNA) NM_001288729 NM_001285917
RefSeq (protein) NP_001275658 NP_001272846
Location (UCSC) Chr 9:
90.11 – 90.32 Mb
Chr 13:
60.6 – 60.76 Mb
PubMed search [1] [2]

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[1]

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[2]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.[3]

References[edit]

  1. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096. 
  2. ^ "Entrez Gene: DAPK1 death-associated protein kinase 1". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]