DAZL

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Deleted in azoospermia-like
Identifiers
Symbols DAZL ; DAZH; DAZL1; DAZLA; SPGYLA
External IDs OMIM601486 HomoloGene1034 GeneCards: DAZL Gene
RNA expression pattern
PBB GE DAZL 206588 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1618 n/a
Ensembl ENSG00000092345 n/a
UniProt Q92904 n/a
RefSeq (mRNA) NM_001190811 n/a
RefSeq (protein) NP_001177740 n/a
Location (UCSC) Chr 3:
16.63 – 16.71 Mb
n/a
PubMed search [1] n/a

Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene.[1]

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males.[2]

Interactions[edit]

DAZL has been shown to interact with DAZ1.[3][4]

References[edit]

  1. ^ Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC (December 1996). "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned". Nat Genet 14 (3): 292–9. doi:10.1038/ng1196-292. PMID 8896558. 
  2. ^ "Entrez Gene: DAZL deleted in azoospermia-like". 
  3. ^ Ruggiu, M; Cooke H J (July 2000). "In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein". Gene (NETHERLANDS) 252 (1-2): 119–26. doi:10.1016/S0378-1119(00)00219-5. ISSN 0378-1119. PMID 10903443. 
  4. ^ Tsui, S; Dai T; Roettger S; Schempp W; Salido E C; Yen P H (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics (UNITED STATES) 65 (3): 266–73. doi:10.1006/geno.2000.6169. ISSN 0888-7543. PMID 10857750. 

Further reading[edit]