|Dachsous 1 (Drosophila)|
|Symbols||; CDH25; CDHR6; FIB1; PCDH16|
Protein dachsous homolog 1, also known as protocadherin-16 (PCDH16) or cadherin-19 (CDH19) or cadherin-25 (CDH25) or fibroblast cadherin-1 (FIB1), is a protein that in humans is encoded by the DCHS1 gene.
This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing.
- "Entrez Gene: dachsous 1 (Drosophila)".
- Matsuyoshi N, Imamura S (June 1997). "Multiple cadherins are expressed in human fibroblasts". Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
- "Mutations in the DCHS1 Gene Cause Mitral Valve Prolapse In Humans". Ashg.org. Retrieved 2013-11-22.
- Rose JE, Behm FM, Drgon T et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Nakajima D, Nakayama M, Kikuno R et al. (2001). "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.". Brain Res. Mol. Brain Res. 94 (1-2): 85–95. doi:10.1016/S0169-328X(01)00218-2. PMID 11597768.
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