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Decapping mRNA 1A
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DCP1A ; HSA275986; Nbla00360; SMAD4IP1; SMIF
External IDs OMIM607010 MGI1923151 HomoloGene10178 GeneCards: DCP1A Gene
RNA expression pattern
PBB GE DCP1A 218508 at tn.png
More reference expression data
Species Human Mouse
Entrez 55802 75901
Ensembl ENSG00000162290 ENSMUSG00000021962
UniProt Q9NPI6 Q91YD3
RefSeq (mRNA) NM_001290204 NM_133761
RefSeq (protein) NP_001277133 NP_598522
Location (UCSC) Chr 3:
53.32 – 53.38 Mb
Chr 14:
30.48 – 30.53 Mb
PubMed search [1] [2]

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.[1]

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.[1]


DCP1A has been shown to interact with DCP2[2] and UPF1.[2]


Further reading[edit]