DCPS (gene)

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Decapping enzyme, scavenger
Protein DCPS PDB 1st0.png
PDB rendering based on 1st0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DCPS ; DCS1; HINT-5; HINT5; HSL1
External IDs OMIM610534 MGI1916555 HomoloGene32202 GeneCards: DCPS Gene
EC number 3.6.1.59
Orthologs
Species Human Mouse
Entrez 28960 69305
Ensembl ENSG00000110063 ENSMUSG00000032040
UniProt Q96C86 Q9DAR7
RefSeq (mRNA) NM_014026 NM_027030
RefSeq (protein) NP_054745 NP_081306
Location (UCSC) Chr 11:
126.17 – 126.22 Mb
Chr 9:
35.12 – 35.18 Mb
PubMed search [1] [2]
Scavenger mRNA decapping enzyme (DcpS) N-terminal
PDB 1vlr EBI.jpg
crystal structure of mrna decapping enzyme (dcps) from mus musculus at 1.83 a resolution
Identifiers
Symbol DcpS
Pfam PF05652
InterPro IPR008594
SCOP 1st4
SUPERFAMILY 1st4
Scavenger mRNA decapping enzyme C-term binding
Identifiers
Symbol DcpS_C
Pfam PF11969
Pfam clan CL0265
SCOP 1st4
SUPERFAMILY 1st4

Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.[1][2][3]

The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP).[4] The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic residues.[5] The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.


References[edit]

  1. ^ Liu H, Rodgers ND, Jiao X, Kiledjian M (Aug 2002). "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases". EMBO J 21 (17): 4699–4708. doi:10.1093/emboj/cdf448. PMC 126188. PMID 12198172. 
  2. ^ van Dijk E, Le Hir H, Seraphin B (Oct 2003). "DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway". Proc Natl Acad Sci U S A 100 (21): 12081–12086. doi:10.1073/pnas.1635192100. PMC 218716. PMID 14523240. 
  3. ^ "Entrez Gene: DCPS decapping enzyme, scavenger". 
  4. ^ Liu H, Kiledjian M (February 2006). "Decapping the message: a beginning or an end". Biochem. Soc. Trans. 34 (Pt 1): 35–8. doi:10.1042/BST20060035. PMID 16246173. 
  5. ^ Han GW, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, Hampton E, Haugen J, Hornsby M, Jaroszewski L, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, McPhillips TM, Miller MD, Moy K, Nigoghossian E, Paulsen J, Quijano K, Reyes R, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA (September 2005). "Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution". Proteins 60 (4): 797–802. doi:10.1002/prot.20467. PMID 16001405. 

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR008594