DCTN2

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Dynactin 2 (p50)
Identifiers
Symbols DCTN2 ; DCTN50; DYNAMITIN; RBP50
External IDs OMIM607376 MGI107733 HomoloGene4667 GeneCards: DCTN2 Gene
RNA expression pattern
PBB GE DCTN2 200932 s at tn.png
PBB GE DCTN2 214384 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10540 69654
Ensembl ENSG00000175203 ENSMUSG00000025410
UniProt Q13561 Q99KJ8
RefSeq (mRNA) NM_001261412 NM_001190453
RefSeq (protein) NP_001248341 NP_001177382
Location (UCSC) Chr 12:
57.92 – 57.94 Mb
Chr 10:
127.27 – 127.28 Mb
PubMed search [1] [2]

Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene.[1][2]

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.[2]

Interactions[edit]

DCTN2 has been shown to interact with MARCKSL1.[3]

References[edit]

  1. ^ Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (July 1996). "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis". J Cell Biol 132 (4): 617–33. doi:10.1083/jcb.132.4.617. PMC 2199864. PMID 8647893. 
  2. ^ a b "Entrez Gene: DCTN2 dynactin 2 (p50)". 
  3. ^ Yue, L; Lu S; Garces J; Jin T; Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. (UNITED STATES) 275 (31): 23948–56. doi:10.1074/jbc.M001845200. ISSN 0021-9258. PMID 10827182. 

Further reading[edit]