DDX17

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DEAD (Asp-Glu-Ala-Asp) box helicase 17
Identifiers
Symbols DDX17 ; P72; RH70
External IDs OMIM608469 MGI1914290 HomoloGene101101 GeneCards: DDX17 Gene
EC number 3.6.4.13
RNA expression pattern
PBB GE DDX17 208151 x at tn.png
PBB GE DDX17 208718 at tn.png
PBB GE DDX17 208719 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10521 67040
Ensembl ENSG00000100201 ENSMUSG00000055065
UniProt Q92841 Q501J6
RefSeq (mRNA) NM_001098504 NM_001040187
RefSeq (protein) NP_001091974 NP_001035277
Location (UCSC) Chr 22:
38.88 – 38.9 Mb
Chr 15:
79.53 – 79.55 Mb
PubMed search [1] [2]

Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.[2]

Interactions[edit]

DDX17 has been shown to interact with HDAC1,[3] Nuclear receptor coactivator 1,[4] Nuclear receptor coactivator 3,[4] Estrogen receptor alpha,[4] Nuclear receptor coactivator 2,[4] SRA1,[4] DDX5 (p68)[5] and DHX9 (RNA Helicase A).[6]

References[edit]

  1. ^ Lamm GM, Nicol SM, Fuller-Pace FV, Lamond AI (Dec 1996). "p72: a human nuclear DEAD box protein highly related to p68". Nucleic Acids Res 24 (19): 3739–47. doi:10.1093/nar/24.19.3739. PMC 146168. PMID 8871553. 
  2. ^ a b "Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17". 
  3. ^ Wilson, Brian J; Bates Gaynor J, Nicol Samantha M, Gregory David J, Perkins Neil D, Fuller-Pace Frances V (Aug 2004). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Mol. Biol. (England) 5: 11. doi:10.1186/1471-2199-5-11. PMC 514542. PMID 15298701. 
  4. ^ a b c d e Watanabe, M; Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (Mar 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. (England) 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. ISSN 0261-4189. PMC 145523. PMID 11250900. 
  5. ^ Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV. (2003). "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. doi:10.1093/nar/gkg236. PMC 149829. PMID 12595555. 
  6. ^ Wilson, Brian J; Giguere V (Nov 2007). "Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis". BMC Genomics (England) 8: 419. doi:10.1186/1471-2164-8-419. PMID 18005418. 

Further reading[edit]