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DEAD (Asp-Glu-Ala-Asp) box helicase 21
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606357 MGI1860494 HomoloGene3473 GeneCards: DDX21 Gene
EC number
RNA expression pattern
PBB GE DDX21 208152 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9188 56200
Ensembl ENSG00000165732 ENSMUSG00000020075
UniProt Q9NR30 Q9JIK5
RefSeq (mRNA) NM_001256910 NM_019553
RefSeq (protein) NP_001243839 NP_062426
Location (UCSC) Chr 10:
70.72 – 70.74 Mb
Chr 10:
62.58 – 62.6 Mb
PubMed search [1] [2]

Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.[2]


DDX21 has been shown to interact with C-jun.[3]


  1. ^ Valdez BC, Henning D, Busch RK, Woods K, Flores-Rozas H, Hurwitz J, Perlaky L, Busch H (Jun 1996). "A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease". Nucleic Acids Res 24 (7): 1220–4. doi:10.1093/nar/24.7.1220. PMC 145780. PMID 8614622. 
  2. ^ a b "Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21". 
  3. ^ Westermarck, Jukka; Weiss Carsten, Saffrich Rainer, Kast Jürgen, Musti Anna-Maria, Wessely Matthias, Ansorge Wilhelm, Séraphin Bertrand, Wilm Matthias, Valdez Benigno C, Bohmann Dirk (Feb 2002). "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription". EMBO J. (England) 21 (3): 451–60. doi:10.1093/emboj/21.3.451. ISSN 0261-4189. PMC 125820. PMID 11823437. 

Further reading[edit]