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DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Symbols DDX23 ; PRPF28; SNRNP100; U5-100K; U5-100KD; prp28
External IDs OMIM612172 MGI1921601 HomoloGene3542 GeneCards: DDX23 Gene
EC number
RNA expression pattern
PBB GE DDX23 40465 at tn.png
PBB GE DDX23 201440 at tn.png
More reference expression data
Species Human Mouse
Entrez 9416 74351
Ensembl ENSG00000174243 ENSMUSG00000003360
UniProt Q9BUQ8 D3Z0M9
RefSeq (mRNA) NM_004818 NM_001080981
RefSeq (protein) NP_004809 NP_001074450
Location (UCSC) Chr 12:
49.22 – 49.25 Mb
Chr 15:
98.65 – 98.66 Mb
PubMed search [1] [2]

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.[1][2][3]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.[3]


Further reading[edit]