DDX27

DDX27
Identifiers
Aliases	DDX27, DRS1, Drs1p, PP3241, RHLP, dJ686N3.1, HSPC259, DEAD-box helicase 27
External IDs	OMIM: 616621 MGI: 2385884 HomoloGene: 6431 GeneCards: DDX27
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.13 Start 49,219,347 bp End 49,244,077 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 166,857,113 bp End 166,876,867 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell endothelial cell sural nerve hair follicle pylorus sperm pericardium cardia lymph node internal globus pallidus Top expressed in otic placode primitive streak yolk sac morula saccule somite lip thymus entorhinal cortex abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus nucleus chromosome cytoplasm Biological process rRNA processing RNA secondary structure unwinding ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55661 228889 Ensembl ENSG00000124228 ENSMUSG00000017999 UniProt Q96GQ7 Q921N6 RefSeq (mRNA) NM_017895 NM_001348187 NM_153065 RefSeq (protein) NP_060365 NP_001335116 NP_694705 Location (UCSC) Chr 20: 49.22 – 49.24 Mb Chr 2: 166.86 – 166.88 Mb PubMed search
Wikidata
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DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human gene.

The protein encoded by this gene belongs to the family of DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.