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Defensin, alpha 5, Paneth cell-specific
Protein DEFA5 PDB 1zmp.png
PDB rendering based on 1zmp.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DEFA5 ; DEF5; HD-5
External IDs OMIM600472 HomoloGene128604 GeneCards: DEFA5 Gene
RNA expression pattern
PBB GE DEFA5 207529 at tn.png
More reference expression data
Species Human Mouse
Entrez 1670 n/a
Ensembl ENSG00000164816 n/a
UniProt Q01523 n/a
RefSeq (mRNA) NM_021010 n/a
RefSeq (protein) NP_066290 n/a
Location (UCSC) Chr 8:
7.06 – 7.06 Mb
PubMed search [1] n/a

Defensin, alpha 5 (DEFA5) also known as human alpha defensin 5 (HD5) is a human protein that is encoded by the DEFA5 gene.[1][2] DEFA5 is expressed in the Paneth cells of the ileum.[3]

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.[1]


  1. ^ a b "Entrez Gene: DEFA5 defensin, alpha 5, Paneth cell-specific". 
  2. ^ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Lett. 315 (2): 187–92. doi:10.1016/0014-5793(93)81160-2. PMID 8417977. 
  3. ^ Zhao C, Wang I, Lehrer RI (24 Nov 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Lett 396 (2–3): 319–22. doi:10.1016/0014-5793(96)01123-4. PMID 8915011. 

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