DEGS2

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Delta(4)-desaturase, sphingolipid 2
Identifiers
Symbols DEGS2 ; C14orf66; DES2; FADS8
External IDs OMIM610862 HomoloGene23617 IUPHAR: 2485 GeneCards: DEGS2 Gene
Orthologs
Species Human Mouse
Entrez 123099 70059
Ensembl ENSG00000168350 ENSMUSG00000021263
UniProt Q6QHC5 Q8R2F2
RefSeq (mRNA) NM_206918 NM_001171002
RefSeq (protein) NP_996801 NP_001164473
Location (UCSC) Chr 14:
100.14 – 100.16 Mb
Chr 12:
108.69 – 108.7 Mb
PubMed search [1] [2]

Delta(4)-desaturase, sphingolipid 2 is a protein that in humans is encoded by the DEGS2 gene.[1]

Function[edit]

This gene encodes a bifunctional enzyme that is involved in the biosynthesis of sphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.