DEK (gene)

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DEK oncogene
Protein DEK PDB 1q1v.png
PDB rendering based on 1q1v.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DEK ; D6S231E
External IDs OMIM125264 MGI1926209 HomoloGene2593 GeneCards: DEK Gene
RNA expression pattern
PBB GE DEK 200934 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7913 110052
Ensembl ENSG00000124795 ENSMUSG00000021377
UniProt P35659 Q7TNV0
RefSeq (mRNA) NM_001134709 NM_025900
RefSeq (protein) NP_001128181 NP_080176
Location (UCSC) Chr 6:
18.22 – 18.27 Mb
Chr 13:
47.08 – 47.11 Mb
PubMed search [1] [2]

Protein DEK is a protein that in humans is encoded by the DEK gene.[1][2]

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[2]

Interactions[edit]

DEK (gene) has been shown to interact with TFAP2A.[3]

References[edit]

  1. ^ von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G (Apr 1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol Cell Biol 12 (4): 1687–97. PMC 369612. PMID 1549122. 
  2. ^ a b "Entrez Gene: DEK DEK oncogene (DNA binding)". 
  3. ^ Campillos, Mónica; García Miguel Angel; Valdivieso Fernando; Vázquez Jesús (Mar 2003). "Transcriptional activation by AP-2α is modulated by the oncogene DEK". Nucleic Acids Res. (England) 31 (5): 1571–5. doi:10.1093/nar/gkg247. PMC 149840. PMID 12595566. 

Further reading[edit]