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Diacylglycerol kinase, alpha 80kDa
Protein DGKA PDB 1tuz.png
PDB rendering based on 1tuz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DGKA ; DAGK; DAGK1; DGK-alpha
External IDs OMIM125855 MGI102952 HomoloGene1028 GeneCards: DGKA Gene
EC number
RNA expression pattern
PBB GE DGKA 203385 at tn.png
PBB GE DGKA 211272 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1606 13139
Ensembl ENSG00000065357 ENSMUSG00000025357
UniProt P23743 O88673
RefSeq (mRNA) NM_001345 NM_016811
RefSeq (protein) NP_001336 NP_058091
Location (UCSC) Chr 12:
56.32 – 56.35 Mb
Chr 10:
128.72 – 128.74 Mb
PubMed search [1] [2]

Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.[1][2][3]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[3]


  1. ^ Hart TC, Champagne C, Zhou J, Van Dyke TE (Jun 1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm Genome 5 (2): 123–4. doi:10.1007/BF00292343. PMID 8180475. 
  2. ^ Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics 22 (1): 246–7. doi:10.1006/geno.1994.1376. PMID 7959783. 
  3. ^ a b "Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa". 

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