DGKB

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Diacylglycerol kinase, beta 90kDa
Identifiers
Symbols DGKB ; DAGK2; DGK; DGK-BETA
External IDs OMIM604070 MGI2442474 HomoloGene37875 GeneCards: DGKB Gene
EC number 2.7.1.107
RNA expression pattern
PBB GE DGKB 216307 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1607 217480
Ensembl ENSG00000136267 ENSMUSG00000036095
UniProt Q9Y6T7 Q6NS52
RefSeq (mRNA) NM_004080 NM_178681
RefSeq (protein) NP_004071 NP_848796
Location (UCSC) Chr 7:
14.18 – 15.01 Mb
Chr 12:
37.88 – 38.63 Mb
PubMed search [1] [2]

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.[1][2]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[2]

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