DGKG

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Diacylglycerol kinase, gamma 90kDa
Identifiers
Symbols DGKG ; DAGK3; DGK-GAMMA
External IDs OMIM601854 MGI105060 HomoloGene1029 ChEMBL: 1075157 GeneCards: DGKG Gene
EC number 2.7.1.107
RNA expression pattern
PBB GE DGKG 206395 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1608 110197
Ensembl ENSG00000058866 ENSMUSG00000022861
UniProt P49619 Q91WG7
RefSeq (mRNA) NM_001080744 NM_138650
RefSeq (protein) NP_001074213 NP_619591
Location (UCSC) Chr 3:
185.82 – 186.08 Mb
Chr 16:
22.47 – 22.66 Mb
PubMed search [1] [2]

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.[1][2]

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References[edit]

  1. ^ Kai M, Sakane F, Imai S, Wada I, Kanoh H (Aug 1994). "Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells". J Biol Chem 269 (28): 18492–8. PMID 8034597. 
  2. ^ a b "Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa". 

Further reading[edit]