DGKQ

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Diacylglycerol kinase, theta 110kDa
Identifiers
Symbols DGKQ ; DAGK; DAGK4; DAGK7
External IDs OMIM601207 MGI102918 HomoloGene20352 GeneCards: DGKQ Gene
EC number 2.7.1.107
RNA expression pattern
PBB GE DGKQ 207562 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1609 110524
Ensembl ENSG00000145214 ENSMUSG00000004815
UniProt P52824 Q6P5E8
RefSeq (mRNA) NM_001347 NM_199011
RefSeq (protein) NP_001338 NP_950176
Location (UCSC) Chr 4:
0.95 – 0.98 Mb
Chr 5:
108.65 – 108.67 Mb
PubMed search [1] [2]

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.[1][2][3]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[3]

Interactions[edit]

DGKQ has been shown to interact with RHOA.[4]

References[edit]

  1. ^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502. 
  2. ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683. 
  3. ^ a b "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa". 
  4. ^ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. (UNITED STATES) 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731. 

Further reading[edit]