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Diacylglycerol kinase, zeta
Symbols DGKZ ; DAGK5; DAGK6; DGK-ZETA; hDGKzeta
External IDs OMIM601441 MGI1278339 HomoloGene37831 GeneCards: DGKZ Gene
EC number
RNA expression pattern
PBB GE DGKZ 207556 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8525 104418
Ensembl ENSG00000149091 ENSMUSG00000040479
UniProt Q13574 Q80UP3
RefSeq (mRNA) NM_001105540 NM_001166597
RefSeq (protein) NP_001099010 NP_001160069
Location (UCSC) Chr 11:
46.35 – 46.4 Mb
Chr 2:
91.93 – 91.98 Mb
PubMed search [1] [2]

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[1][2]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[2]


DGKZ has been shown to interact with P110α.[3]


  1. ^ Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem 271 (17): 10230–6. doi:10.1074/jbc.271.17.10230. PMID 8626588. 
  2. ^ a b "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa". 
  3. ^ Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. (United States) 278 (41): 39542–7. doi:10.1074/jbc.M307153200. ISSN 0021-9258. PMID 12890670. 

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