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This article is about the gene coding for the enzyme deoxyhypusine synthase. For another enzyme commonly abbreviated DHPS, see Dihydropteroate synthetase. For other uses, see DHPS (disambiguation).
Deoxyhypusine synthase
Protein DHPS PDB 1dhs.png
PDB rendering based on 1dhs.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DHPS ; DHS; DS; MIG13
External IDs OMIM600944 MGI2683592 HomoloGene1453 ChEMBL: 4415 GeneCards: DHPS Gene
EC number
RNA expression pattern
PBB GE DHPS 211558 s at tn.png
PBB GE DHPS 202802 at tn.png
PBB GE DHPS 207831 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1725 330817
Ensembl ENSG00000095059 ENSMUSG00000060038
UniProt P49366 Q3TXU5
RefSeq (mRNA) NM_001206974 NM_001039514
RefSeq (protein) NP_001193903 NP_001034603
Location (UCSC) Chr 19:
12.79 – 12.79 Mb
Chr 8:
85.07 – 85.08 Mb
PubMed search [1] [2]

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.[1][2]

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.[2]


  1. ^ Joe YA, Wolff EC, Park MH (Oct 1995). "Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins". J Biol Chem 270 (38): 22386–92. doi:10.1074/jbc.270.38.22386. PMID 7673224. 
  2. ^ a b "Entrez Gene: DHPS deoxyhypusine synthase". 

Further reading[edit]