DHRS2

DHRS2
Identifiers
Aliases	DHRS2, HEP27, SDR25C1, dehydrogenase/reductase (SDR family) member 2, dehydrogenase/reductase 2
External IDs	OMIM: 615194 HomoloGene: 68486 GeneCards: DHRS2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,645,639 bp
RNA expression pattern
	Top expressed in
	mucosa of urinary bladder; ; islet of Langerhans; ; parotid gland; ; right lobe of liver; ; spleen; ; nipple; ; amniotic fluid; ; placenta; ; sperm; ; body of pancreas;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; protein binding; carbonyl reductase (NADPH) activity;
Cellular component	cytoplasm; mitochondrial matrix; nuclear envelope; mitochondrion; nucleus;
Biological process	cellular response to oxidative stress; myeloid dendritic cell differentiation; negative regulation of apoptotic process; response to toxic substance; C21-steroid hormone metabolic process; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	10202
	n/a
	ENSG00000100867
	n/a
	Q13268
	n/a
	NM_005794; NM_182908; NM_001318835
	n/a
	NP_001305764; NP_005785; NP_878912
	n/a
	Wikidata
View/Edit Human

Dehydrogenase/reductase SDR family member 2 is an enzyme that in humans is encoded by the DHRS2 gene.^[3]^[4]^[5]^[6]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100867 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gabrielli F, Donadel G, Bensi G, Heguy A, Melli M (Nov 1995). "A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family". Eur J Biochem. 232 (2): 473–7. doi:10.1111/j.1432-1033.1995.473zz.x. PMID 7556196.
^ Heinz S, Krause SW, Gabrielli F, Wagner HM, Andreesen R, Rehli M (Apr 2002). "Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells". Genomics. 79 (4): 608–15. doi:10.1006/geno.2002.6743. PMID 11944995.
^ Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jornvall H, Oppermann U (Jun 2006). "Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue". Cell Mol Life Sci. 63 (10): 1205–13. doi:10.1007/s00018-006-6013-y. PMID 16685466. S2CID 24562253.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: DHRS2 dehydrogenase/reductase (SDR family) member 2".

External links[edit]

DHRS2 human gene location in the UCSC Genome Browser.
DHRS2 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100867 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7556196-3] Gabrielli F, Donadel G, Bensi G, Heguy A, Melli M (Nov 1995). "A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family". Eur J Biochem. 232 (2): 473–7. doi:10.1111/j.1432-1033.1995.473zz.x. PMID 7556196.

[pmid11944995-4] Heinz S, Krause SW, Gabrielli F, Wagner HM, Andreesen R, Rehli M (Apr 2002). "Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells". Genomics. 79 (4): 608–15. doi:10.1006/geno.2002.6743. PMID 11944995.

[pmid16685466-5] Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U, Gabrielli F, Lardy H, Jornvall H, Oppermann U (Jun 2006). "Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue". Cell Mol Life Sci. 63 (10): 1205–13. doi:10.1007/s00018-006-6013-y. PMID 16685466. S2CID 24562253.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-7] "Entrez Gene: DHRS2 dehydrogenase/reductase (SDR family) member 2".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

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