DKK1

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Dickkopf WNT signaling pathway inhibitor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DKK1 ; DKK-1; SK
External IDs OMIM605189 MGI1329040 HomoloGene7689 ChEMBL: 6024 GeneCards: DKK1 Gene
RNA expression pattern
PBB GE DKK1 204602 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22943 13380
Ensembl ENSG00000107984 ENSMUSG00000024868
UniProt O94907 O54908
RefSeq (mRNA) NM_012242 NM_010051
RefSeq (protein) NP_036374 NP_034181
Location (UCSC) Chr 10:
54.07 – 54.08 Mb
Chr 19:
30.55 – 30.55 Mb
PubMed search [1] [2]

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.[1]

Function[edit]

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow, plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.[1]

Interactions[edit]

DKK1 has been shown to interact with LRP6.[2]

Clinical significance[edit]

DKK1 is one of the most upregulated genes in androgen-potentiated balding, with DKK-1 messenger RNA upregulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing body against DKK-1 reversed DHT effects on outer root sheath keratinocytes.[3] DKK-1 expression is attenuated by L-threonate in vitro, with the latter a metabolite of ascorbate.[4]

References[edit]

  1. ^ a b "Entrez Gene: DKK1 dickkopf homolog 1 (Xenopus laevis)". 
  2. ^ Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–61. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. 
  3. ^ Kwack MH, Sung YK, Chung EJ, Im SU, Ahn JS, Kim MK, Kim JC (2008). "Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes". J. Invest. Dermatol. 128 (2): 262–9. doi:10.1038/sj.jid.5700999. PMID 17657240. 
  4. ^ Kwack MH, Ahn JS, Kim MK, Kim JC, Sung YK (2010). "Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells". BMB Rep 43 (10): 688–92. doi:10.5483/BMBRep.2010.43.10.688. PMID 21034532. 

Further reading[edit]