DLX1

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Distal-less homeobox 1
Identifiers
Symbol DLX1
External IDs OMIM600029 MGI94901 HomoloGene22558 GeneCards: DLX1 Gene
Orthologs
Species Human Mouse
Entrez 1745 13390
Ensembl ENSG00000144355 ENSMUSG00000041911
UniProt P56177 Q64317
RefSeq (mRNA) NM_001038493 NM_010053
RefSeq (protein) NP_001033582 NP_034183
Location (UCSC) Chr 2:
172.95 – 172.95 Mb
Chr 2:
71.53 – 71.53 Mb
PubMed search [1] [2]

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.[1][2]

Function[edit]

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

References[edit]

  1. ^ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794. 
  2. ^ a b = gene&Cmd = ShowDetailView&TermToSearch = 1745 "Entrez Gene: DLX1 distal-less homeobox 1". 

Further reading[edit]