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Distal-less homeobox 1
Symbol DLX1
External IDs OMIM600029 MGI94901 HomoloGene22558 GeneCards: DLX1 Gene
Species Human Mouse
Entrez 1745 13390
Ensembl ENSG00000144355 ENSMUSG00000041911
UniProt P56177 Q64317
RefSeq (mRNA) NM_001038493 NM_010053
RefSeq (protein) NP_001033582 NP_034183
Location (UCSC) Chr 2:
172.95 – 172.95 Mb
Chr 2:
71.53 – 71.53 Mb
PubMed search [1] [2]

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.[1][2]


This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.[2]


  1. ^ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794. 
  2. ^ a b = gene&Cmd = ShowDetailView&TermToSearch = 1745 "Entrez Gene: DLX1 distal-less homeobox 1". 

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