Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
^Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID1354641.
Harris SE, Guo D, Harris MA et al. (2003). "Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors". Front. Biosci.8: s1249–65. doi:10.2741/1170. PMID12957859.
Qiu M, Bulfone A, Martinez S et al. (1995). "Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain". Genes Dev.9 (20): 2523–38. doi:10.1101/gad.9.20.2523. PMID7590232.
Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res.130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID11675124.
Espinoza HM, Ganga M, Vadlamudi U et al. (2005). "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein". Biochemistry44 (10): 3942–54. doi:10.1021/bi048362x. PMID15751970.