Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Specifically, colocalization of phosphorylatedSmad1 / 5 / 8 complex and Dlx3 regulate role for BMP signaling to Dlx3 during hair morphogenesis in animal models.
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17.
^Scherer SW, Heng HH, Robinson GW, Mahon KA, Evans JP, Tsui LC (Aug 1995). "Assignment of the human homolog of mouse Dlx3 to chromosome 17q21.3-q22 by analysis of somatic cell hybrids and fluorescence in situ hybridization". Mamm Genome6 (4): 310–1. doi:10.1007/BF00352432. PMID7613049.
Price JA, Bowden DW, Wright JT et al. (1998). "Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome". Hum. Mol. Genet.7 (3): 563–9. doi:10.1093/hmg/7.3.563. PMID9467018.
Roberson MS, Meermann S, Morasso MI et al. (2001). "A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells". J. Biol. Chem.276 (13): 10016–24. doi:10.1074/jbc.M007481200. PMID11113121.
Peng L, Payne AH (2002). "AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6". J. Biol. Chem.277 (10): 7945–54. doi:10.1074/jbc.M106765200. PMID11773066.
Imabayashi H, Mori T, Gojo S et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res.288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID12878157.
Holland MP, Bliss SP, Berghorn KA, Roberson MS (2004). "A role for CCAAT/enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells". Endocrinology145 (3): 1096–105. doi:10.1210/en.2003-0777. PMID14670999.
Haldeman RJ, Cooper LF, Hart TC et al. (2005). "Increased bone density associated with DLX3 mutation in the tricho-dento-osseous syndrome". Bone35 (4): 988–97. doi:10.1016/j.bone.2004.06.003. PMID15454107.
Dong J, Amor D, Aldred MJ et al. (2005). "DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism". Am. J. Med. Genet. A133 (2): 138–41. doi:10.1002/ajmg.a.30521. PMID15666299.
Islam M, Lurie AG, Reichenberger E (2006). "Clinical features of tricho-dento-osseous syndrome and presentation of three new cases: an addition to clinical heterogeneity". Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics100 (6): 736–42. doi:10.1016/j.tripleo.2005.04.017. PMID16301156.
Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res.12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Morsczeck C (2006). "Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro". Calcif. Tissue Int.78 (2): 98–102. doi:10.1007/s00223-005-0146-0. PMID16467978.
Berghorn KA, Clark-Campbell PA, Han L et al. (2006). "Smad6 represses Dlx3 transcriptional activity through inhibition of DNA binding". J. Biol. Chem.281 (29): 20357–67. doi:10.1074/jbc.M603049200. PMID16687405.