DMBT1

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Deleted in malignant brain tumors 1
Identifiers
Symbols DMBT1 ; GP340; muclin
External IDs OMIM601969 MGI106210 HomoloGene68990 GeneCards: DMBT1 Gene
RNA expression pattern
PBB GE DMBT1 208250 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1755 12945
Ensembl ENSG00000187908 ENSMUSG00000047517
UniProt Q9UGM3 Q60997
RefSeq (mRNA) NM_004406 NM_007769
RefSeq (protein) NP_004397 NP_031795
Location (UCSC) Chr 10:
124.32 – 124.4 Mb
Chr 7:
131.03 – 131.12 Mb
PubMed search [1] [2]

Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.[1][2]

Function[edit]

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.[3]

Interactions[edit]

DMBT1 has been shown to interact with Surfactant protein D.[4][5]

References[edit]

  1. ^ Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A (Oct 1997). "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours". Nat Genet 17 (1): 32–9. doi:10.1038/ng0997-32. PMID 9288095. 
  2. ^ Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Folsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S (Jun 2007). "Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion". J Immunol 178 (12): 8203–11. doi:10.4049/jimmunol.178.12.8203. PMID 17548659. 
  3. ^ "Entrez Gene: DMBT1 deleted in malignant brain tumors 1". 
  4. ^ Tino MJ, Wright JR (1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009. 
  5. ^ Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228. 

Further reading[edit]