For the video game, see Devil May Cry
|DNA meiotic recombinase 1|
PDB rendering based on 1v5w.
|Symbols||; DMC1H; LIM15; dJ199H16.1|
|RNA expression pattern|
Meiotic recombination protein Dmc1 is a homolog of the bacterial strand exchange protein RecA. Dmc1 plays the central role in homologous recombination in meiosis by assembling at the sites of programmed DNA double strand breaks and carrying out a search for allelic DNA sequences located on homologous chromatids. The name "Dmc" stands for "disrupted meiotic cDNA" and refers to the method used for its discovery which involved using clones from a meiosis-specific cDNA library to direct knock-out mutations of abundantly expressed meiotic genes. The Dmc1 protein is one of two homologs of RecA found in eukaryotic cells, the other being Rad51. In budding yeast, Rad51 serves as a strand exchange protein in mitosis where it is critical for the repair of DNA breaks. Rad51 is converted to an accessory factor for Dmc1 during meiosis by inhibition of its strand exchange activity. Homologs of DMC1 have been identified in many organisms including divergent fungi, plants and mammals including humans.
The DMC1 gene and protein were discovered in the budding yeast S. cerevisiae by Douglas Bishop when he was a postdoctoral fellow in the laboratory of Nancy Kleckner at Harvard University.
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information and is essential for the reductional segregation of chromosomes that must occur for formation of gametes during sexual reproduction.
DMC1 (gene) has been shown to interact with RAD51. The protein has also been shown to bind Tid1(Rdh54), Mei5/Sae3, and Hop2/Mnd1. All of these interacting proteins act to enhance Dmc1's activity in purified systems and are also implicated as being required for Dmc1 function in cells.
- Habu T, Taki T, West A, Nishimune Y, Morita T (1996). "The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis". Nucleic Acids Res. 24 (3): 470–7. doi:10.1093/nar/24.3.470. PMC 145652. PMID 8602360.
- Sato S, Seki N, Hotta Y, Tabata S (1995). "Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes". DNA Res. 2 (4): 183–6. doi:10.1093/dnares/2.4.183. PMID 8590282.
- Thorslund T, Esashi F, West S (2007). "Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1". EMBO J. 26 (12): 2915–22. doi:10.1038/sj.emboj.7601739. PMC 1894777. PMID 17541404.
- "Entrez Gene: DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)".
- Cloud V, Chan Y, Grubb J, Budke B, Bishop D (2012). "Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis". Science 337 (6099): 1222–5. doi:10.1126/science.1219379. PMID 22955832.
- Bishop D, Park D, Xu L, Kleckner N (1992). "DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression". Cell 69 (3): 439–56. doi:10.1016/0092-8674(92)90446-j. PMID 1581960.
- Masson J, Davies A, Hajibagheri N, Van Dyck E, Benson F, Stasiak A et al. (Nov 1999). "The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51". EMBO J. 18 (22): 6552–60. doi:10.1093/emboj/18.22.6552. PMC 1171718. PMID 10562567.
- Golub E, Gupta R, Haaf T, Wold M, Radding C (1998). "Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA". Nucleic Acids Res. 26 (23): 5388–93. doi:10.1093/nar/26.23.5388. PMC 148005. PMID 9826763.
- Masson J, Davies A, Hajibagheri N, Van Dyck E, Benson F, Stasiak A et al. (1999). "The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51". EMBO J. 18 (22): 6552–60. doi:10.1093/emboj/18.22.6552. PMC 1171718. PMID 10562567.
- Dunham I, Shimizu N, Roe B, Chissoe S, Hunt A, Collins J et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Moens P, Kolas N, Tarsounas M, Marcon E, Cohen P, Spyropoulos B (2002). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination". J. Cell. Sci. 115 (Pt 8): 1611–22. PMID 11950880.
- Habu T, Wakabayashi N, Yoshida K, Yomogida K, Nishimune Y, Morita T (2004). "p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis". Carcinogenesis 25 (6): 889–93. doi:10.1093/carcin/bgh099. PMID 14764457.
- Kinebuchi T, Kagawa W, Enomoto R, Tanaka K, Miyagawa K, Shibata T et al. (2004). "Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1". Mol. Cell 14 (3): 363–74. doi:10.1016/S1097-2765(04)00218-7. PMID 15125839.
- Sehorn M, Sigurdsson S, Bussen W, Unger V, Sung P (2004). "Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange". Nature 429 (6990): 433–7. doi:10.1038/nature02563. PMID 15164066.
- Collins J, Wright C, Edwards C, Davis M, Grinham J, Cole C et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Kinebuchi T, Kagawa W, Kurumizaka H, Yokoyama S (2005). "Role of the N-terminal domain of the human DMC1 protein in octamer formation and DNA binding". J. Biol. Chem. 280 (31): 28382–7. doi:10.1074/jbc.M503372200. PMID 15917243.
- Bugreev D, Golub E, Stasiak A, Stasiak A, Mazin A (2005). "Activation of human meiosis-specific recombinase Dmc1 by Ca2+". J. Biol. Chem. 280 (29): 26886–95. doi:10.1074/jbc.M502248200. PMID 15917244.
- Rual J, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Pezza R, Voloshin O, Vanevski F, Camerini-Otero R (2007). "Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing". Genes Dev. 21 (14): 1758–66. doi:10.1101/gad.1562907. PMC 1920170. PMID 17639081.
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