DNA-(apurinic or apyrimidinic site) lyase

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DNA-(apurinic or apyrimidinic site) lyase
Identifiers
EC number 4.2.99.18
CAS number 61811-29-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) is an enzyme that catalyzes the chemical reaction

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that cleave carbon-oxygen bonds. The systematic name of this enzyme class is DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase. Other names in common use include AP lyase, AP endonuclease class I, endodeoxyribonuclease (apurinic or apyrimidinic), deoxyribonuclease (apurinic or apyrimidinic), E. coli endonuclease III, phage-T4 UV endonuclease, Micrococcus luteus UV endonuclease, AP site-DNA 5'-phosphomonoester-lyase, and X-ray endonuclease III.

Structural studies[edit]

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes 1BIX, 1CQG, 1CQH, 1DE8, 1DE9, 1DEW, 1E9N, 1HD7, 1N39, 1N3A, 1N3C, 1VYB, 2ABK, 2I5W, 2ISI, 2J63, 2NOB, 2NOE, 2NOF, 2NOH, 2NOI, 2NOL, and 2NOZ.

References[edit]