DNASTAR

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DNASTAR, Inc.
Type Privately held company
Industry Bioinformatics Software
Founders Dr. Fredrick Blattner, John Schroeder
Headquarters Madison, Wisconsin, United States
Area served Worldwide
Products Lasergene, ArrayStar, GenVision, SeqMan NGen
Website DNASTAR

DNASTAR is a bioinformatics software company headquartered in Madison, WI that develops desktop computer software for DNA, RNA, and protein sequence analysis, including Sanger and next-generation sequence assembly.

History[edit]

DNASTAR was incorporated in 1984. Its primary software product, Lasergene, is used by molecular biology researchers and geneticists for DNA and protein sequence assembly and analysis.[1]

The initial version of Lasergene was released in 1986, and it has since grown in its capabilities. The latest version, Lasergene 10, was released in March 2012.[2] The software supports virtual restriction enzyme cloning as well as TOPO cloning, and cloning using the Gateway technology. Lasergene has also added the functions to do BLAST and FASTA search and utilize multiple alignment methods including Clustal.

In June 2007, the company introduced its ArrayStar software for microarray gene expression analysis. The latest version of ArrayStar, version 5.0, which was released in 2011, also includes an optional module, QSeq, to allow scientists to visualize and analyze RNA-Seq and ChIP-Seq data using the same tools as are used for microarray gene expression.

In October 2007, the company introduced SeqMan NGen to assemble data from Next Generation sequencing platforms. When used along with Lasergene, SeqMan NGen permits researchers to assemble and analyze data from sequencing projects from both traditional and next generation sequencing technologies. Lasergene's use in Next Generation sequence assembly and analysis software was contributed as a chapter, written by company scientists, to the 2008 book Next Generation Genome Sequencing edited by Michael Janitz. [3]

In 2008, DNASTAR was awarded a Reader's Choice Gold Award by Scientific Computing Magazine for the Lasergene sequence analysis software.[4]

The 2008 book Inventing Entrepreneurs: Technology Innovators and their Entrepreneurial Journey by Gerard George and Adam J. Bock includes DNASTAR as an example of an innovative and entrepreneurial success story. [5]

A research study by BMC Genomics in 2010 determined that SeqMan assemblies performed best, with more novel sequences and better recapitulation of transcripts. [6]

Another BMC Genomics study in 2011 determined that the best overall contig performance resulted from a SeqMan NGen assembly. [7]

Software[edit]

  • Lasergene Core Suite is a suite of ten software modules used for molecular biology analysis including gene discovery, primer design, and sequence alignment. These modules include:
    • SeqBuilder – Sequence editing and annotation, automated virtual cloning, and primer design
    • MegAlign – DNA and protein sequence alignments and analysis
    • SeqMan Pro – Contig assembly and analysis, including SNP discovery, coverage evaluation, and project annotation
    • GeneQuest – Gene discovery and annotation
    • Protean 3D – Exploring macromolecular structure, motion, and function
    • Protean – Protein structure analysis and prediction
    • SeqNinja – Advanced editing of genome sequences
    • GenVision – Creating publication-quality illustrations
    • PrimerSelect – primer design
    • EditSeq – Importing and editing unusual file types
  • Lasergene Genomics Suite supports all major next-gen and third-gen sequencing technologies, and performs next-gen sequence assembly and analysis. This software package provides solutions for ‘’De novo’’ and reference-guided genomes, ‘’De novo’’ transcriptomes, exomes, and more. Software modules include:
    • SeqMan NGen – Next-Gen sequence assembly
    • ArrayStar – Large-scale, multi-sample variation comparisons
    • QSeq – RNA-Seq and ChIP-Seq Analysis

See also[edit]

References[edit]

  1. ^ "Company Profile". DNASTAR. Retrieved 27 March 2010. 
  2. ^ "DNASTAR Releases Lasergene 10 Software and SeqNinja". DNASTAR. Retrieved 30 July 2012. 
  3. ^ Janitz, Michal (November 2008). Next-Generation Genome Sequencing: Towards Personalized Medicine. Wiley-VCH. ISBN 978-3-527-32090-5. 
  4. ^ "Bioinformatics Readers' Choice — Gold Award: Lasergene". Advantage Business Media. Retrieved 27 March 2010. 
  5. ^ Gerry, George; Adam Bock (January 2008). Inventing Entrepreneurs: Technology Innovators and their Entrepreneurial Journey. Prentice Hall. ISBN 978-0-13-157470-0. 
  6. ^ "Comparing ‘’de novo’’ assemblers for 454 transcriptome data". BMC Genomics. Retrieved 30 July 2012. 
  7. ^ "Short read Illumina data for the ‘’de novo’’ assembly of a non-model snail species transcriptome (‘’Radix balthica’’, Basommatophora, Pulmonata), and a comparison of assembler performance". BMC Genomics. Retrieved 30 July 2012. 

External links[edit]