DNA damage-inducible transcript 3

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DNA-damage-inducible transcript 3
Identifiers
Symbols DDIT3 ; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153
External IDs OMIM126337 MGI109247 HomoloGene3012 GeneCards: DDIT3 Gene
RNA expression pattern
PBB GE DDIT3 209383 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1649 13198
Ensembl ENSG00000175197 ENSMUSG00000025408
UniProt P35638 P35639
RefSeq (mRNA) NM_001195053 NM_007837
RefSeq (protein) NP_001181982 NP_031863
Location (UCSC) Chr 12:
57.91 – 57.91 Mb
Chr 10:
127.29 – 127.3 Mb
PubMed search [1] [2]

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a transcription factor that is encoded by the DDIT3 gene.[1][2]

Interactions[edit]

DNA damage-inducible transcript 3 has been shown to interact with:

References[edit]

  1. ^ Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (March 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol 11 (2): 1009–16. PMC 359769. PMID 1990262. 
  2. ^ "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3". 
  3. ^ Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. 16 (3): 1157–68. PMC 231098. PMID 8622660. 
  4. ^ a b c Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780. PMID 10523647. 
  5. ^ Hattori T, Ohoka N, Hayashi H, Onozaki K (April 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. 541 (1-3): 33–9. doi:10.1016/s0014-5793(03)00283-7. PMID 12706815. 
  6. ^ Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ (June 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. PMID 8662954. 
  7. ^ Ubeda M, Habener JF (October 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation". J. Biol. Chem. 278 (42): 40514–20. doi:10.1074/jbc.M306404200. PMID 12876286. 
  8. ^ Cui K, Coutts M, Stahl J, Sytkowski AJ (March 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. 275 (11): 7591–6. doi:10.1074/jbc.275.11.7591. PMID 10713066. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.