DOC2A

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Double C2-like domains, alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DOC2A ; Doc2
External IDs OMIM604567 MGI109446 HomoloGene2657 GeneCards: DOC2A Gene
RNA expression pattern
PBB GE DOC2A 205744 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8448 13446
Ensembl ENSG00000149927 ENSMUSG00000052301
UniProt Q14183 Q7TNF0
RefSeq (mRNA) NM_001282062 NM_010069
RefSeq (protein) NP_001268991 NP_034199
Location (UCSC) Chr 16:
30.02 – 30.03 Mb
Chr 7:
126.85 – 126.85 Mb
PubMed search [1] [2]

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[1][2][3]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.[3]

Interactions[edit]

DOC2A has been shown to interact with UNC13B.[4][2]

References[edit]

  1. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360. 
  2. ^ a b Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751. 
  3. ^ a b "Entrez Gene: DOC2A double C2-like domains, alpha". 
  4. ^ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900. 

Further reading[edit]

  • Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557. 
  • Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738. 
  • Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.