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Double C2-like domains, alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DOC2A ; Doc2
External IDs OMIM604567 MGI109446 HomoloGene2657 GeneCards: DOC2A Gene
RNA expression pattern
PBB GE DOC2A 205744 at tn.png
More reference expression data
Species Human Mouse
Entrez 8448 13446
Ensembl ENSG00000149927 ENSMUSG00000052301
UniProt Q14183 Q7TNF0
RefSeq (mRNA) NM_001282062 NM_010069
RefSeq (protein) NP_001268991 NP_034199
Location (UCSC) Chr 16:
30.02 – 30.03 Mb
Chr 7:
126.85 – 126.85 Mb
PubMed search [1] [2]

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[1][2][3]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.[3]


DOC2A has been shown to interact with UNC13B.[4][2]


  1. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360. 
  2. ^ a b Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751. 
  3. ^ a b "Entrez Gene: DOC2A double C2-like domains, alpha". 
  4. ^ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900. 

Further reading[edit]

  • Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557. 
  • Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738. 
  • Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.