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Double C2-like domains, beta
Symbols DOC2B ; DOC2BL
External IDs OMIM604568 MGI1100497 HomoloGene20796 GeneCards: DOC2B Gene
Species Human Mouse
Entrez 8447 13447
Ensembl ENSG00000187939 ENSMUSG00000020848
UniProt Q14184 P70169
RefSeq (mRNA) NM_003585 NM_007873
RefSeq (protein) NP_003576 NP_031899
Location (UCSC) Chr 17:
0.01 – 0.03 Mb
Chr 11:
75.77 – 75.8 Mb
PubMed search [1] [2]

Double C2-like domain-containing protein beta is a protein that in humans is encoded by the DOC2B gene.[1][2]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. Doc2b enhances Ca(2+)-dependent exocytosis in adipocytes,[3] chromaffin cells of the adrenal gland[4] and beta cells in the pancreas.[5] In the central nervous system, Doc2b contributes to the spontaneous release of neurotransmitters by acting as a high-affinity Ca(2+) sensor for exocytosis of synaptic vesicles [6]


  1. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360. 
  2. ^ "Entrez Gene: DOC2B double C2-like domains, beta". 
  3. ^ Fukuda N, Emoto M, Nakamori Y, Taguchi A, Miyamoto S, Uraki S, Oka Y, Tanizawa Y. (Feb 2009). "DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes". Diabetes 58 (2): 377–84. doi:10.2337/db08-0303. PMC 2628611. PMID 19033398. 
  4. ^ Friedrich R, Groffen AJ, Connell E, van Weering JR, Gutman O, Henis YI, Davletov B, Ashery U (Jul 2008). "DOC2B acts as a calcium switch and enhances vesicle fusion". J Neurosci 28 (27): 6794–806. doi:10.1523/JNEUROSCI.0538-08.2008. PMC 2673511. PMID 18596155. 
  5. ^ Miyazaki M, Emoto M, Fukuda N, Hatanaka M, Taguchi A, Miyamoto S, Tanizawa Y (Jul 2009). "DOC2b is a SNARE regulator of glucose-stimulated delayed insulin secretion". Biochem Biophys Res Commun 384 (4): 461–5. doi:10.1016/j.bbrc.2009.04.133. PMID 19410553. 
  6. ^ Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M (Mar 2010). "Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release". Science 327 (5973): 1614–8. doi:10.1126/science.1183765. PMC 2846320. PMID 20150444. 

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