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Docking protein 5
Protein DOK5 PDB 1j0w.png
PDB rendering based on 1j0w.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DOK5 ; C20orf180; IRS-6; IRS6
External IDs OMIM608334 MGI1924079 HomoloGene10195 GeneCards: DOK5 Gene
RNA expression pattern
PBB GE DOK5 214844 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55816 76829
Ensembl ENSG00000101134 ENSMUSG00000027560
UniProt Q9P104 Q91ZM9
RefSeq (mRNA) NM_001294161 NM_001163686
RefSeq (protein) NP_001281090 NP_001157158
Location (UCSC) Chr 20:
53.09 – 53.27 Mb
Chr 2:
170.73 – 170.88 Mb
PubMed search [1] [2]

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[1][2]


The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[2]


DOK5 has been shown to interact with RET proto-oncogene.[3][1]


  1. ^ a b Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J Cell Biol 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823. 
  2. ^ a b "Entrez Gene: DOK5 docking protein 5". 
  3. ^ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081. 

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