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DOT1-like histone H3K79 methyltransferase
Protein DOT1L PDB 1nw3.png
PDB rendering based on 1nw3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DOT1L ; DOT1; KMT4
External IDs OMIM607375 MGI2143886 HomoloGene32779 IUPHAR: 2650 ChEMBL: 1795117 GeneCards: DOT1L Gene
EC number
RNA expression pattern
PBB GE DOT1L 214865 at tn.png
More reference expression data
Species Human Mouse
Entrez 84444 208266
Ensembl ENSG00000104885 ENSMUSG00000061589
UniProt Q8TEK3 Q6XZL8
RefSeq (mRNA) NM_032482 NM_199322
RefSeq (protein) NP_115871 NP_955354
Location (UCSC) Chr 19:
2.16 – 2.23 Mb
Chr 10:
80.76 – 80.8 Mb
PubMed search [1] [2]

DOT1-like, histone H3 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.[1]


Further reading[edit]

  • Nagase T, Nakayama M, Nakajima D et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906. 
  • Feng Q, Wang H, Ng HH et al. (2002). "Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.". Curr. Biol. 12 (12): 1052–8. doi:10.1016/S0960-9822(02)00901-6. PMID 12123582. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Min J, Feng Q, Li Z et al. (2003). "Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.". Cell 112 (5): 711–23. doi:10.1016/S0092-8674(03)00114-4. PMID 12628190. 
  • Jikuya H, Takano J, Kikuno R et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Okada Y, Feng Q, Lin Y et al. (2005). "hDOT1L links histone methylation to leukemogenesis.". Cell 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025. 
  • Sistayanarain A, Tsuneyama K, Zheng H et al. (2006). "Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma.". Anticancer Res. 26 (5A): 3585–93. PMID 17094487.