DPH1

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Diphthamide biosynthesis 1
Identifiers
Symbols DPH1 ; DPH2L; DPH2L1; OVCA1
External IDs OMIM603527 HomoloGene1059 GeneCards: DPH1 Gene
Orthologs
Species Human Mouse
Entrez 1801 116905
Ensembl ENSG00000108963 ENSMUSG00000078789
UniProt Q9BZG8 Q5NCQ5
RefSeq (mRNA) NM_001383 NM_144491
RefSeq (protein) NP_001374 NP_652762
Location (UCSC) Chr 17:
1.93 – 1.95 Mb
Chr 11:
75.18 – 75.19 Mb
PubMed search [1] [2]

Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene.[1][2][3] It encodes a protein that performs posttranslational modification of histidine-715[4] on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.

References[edit]

  1. ^ Phillips NJ, Zeigler MR, Deaven LL (May 1996). "A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3". Cancer Lett 102 (1-2): 85–90. doi:10.1016/0304-3835(96)04169-9. PMID 8603384. 
  2. ^ Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH (Oct 2004). "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol 24 (21): 9487–97. doi:10.1128/MCB.24.21.9487-9497.2004. PMC 522255. PMID 15485916. 
  3. ^ "Entrez Gene: DPH1 DPH1 homolog (S. cerevisiae)". 
  4. ^ Webb TR, Cross SH, McKie L, Edgar R, Vizor L, Harrison J, Peters J, Jackson IJ (2008). "Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development". J. Cell. Sci. 121 (Pt 19): 3140–5. doi:10.1242/jcs.035550. PMC 2592597. PMID 18765564. Diphthamide modification is present in all eukaryotic organisms, in which it is restricted to a histidine residue of translation elongation factor 2 (eEF2, also known as EFT1; position 715 in mammals and 699 in yeast) 

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