DPI-3290

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DPI-3290
Structure of DPI-3290.png
Systematic (IUPAC) name
(+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide
Clinical data
Legal status ?
Identifiers
CAS number 182417-73-8 N
ATC code ?
PubChem CID 5242141
Chemical data
Formula C30H34FN3O2 
Mol. mass 487.607 g/mol
 N (what is this?)  (verify)

DPI-3290 was discovered by Delta Pharmaceutical [1] and is a drug that is used in scientific research. It is a potent analgesic drug,[2] which produces little respiratory depression.[3]

DPI-3290 acts as an agonist at both μ- and δ-opioid receptor, with an IC50 of 6.2nM at μ and 1.0nM at δ.[4]

References[edit]

  1. ^ US Patent 5552404 - Opioid compounds and methods for using same
  2. ^ Gengo, PJ; Pettit, HO; O'Neill, SJ; Wei, K; McNutt, R; Bishop, MJ; Chang, KJ (2003). "DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. I. A mixed opioid agonist with potent antinociceptive activity". The Journal of Pharmacology and Experimental Therapeutics 307 (3): 1221–6. doi:10.1124/jpet.103.054361. PMID 14534368. 
  3. ^ Gengo, PJ; Pettit, HO; O'Neill, SJ; Su, YF; McNutt, R; Chang, KJ (2003). "DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function". The Journal of Pharmacology and Experimental Therapeutics 307 (3): 1227–33. doi:10.1124/jpet.103.054429. PMID 14534367. 
  4. ^ Ananthan S. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS Journal. 2006 Mar 10;8(1):E118-25. doi:10.1208/aapsj080114 PMID 16584118