DPP10

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Dipeptidyl-peptidase 10 (non-functional)
Identifiers
Symbols DPP10 ; DPL2; DPPY; DPRP3
External IDs OMIM608209 MGI2442409 HomoloGene41400 GeneCards: DPP10 Gene
RNA expression pattern
PBB GE DPP10 gnf1h06059 at tn.png
PBB GE DPP10 gnf1h06976 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57628 269109
Ensembl ENSG00000175497 ENSMUSG00000036815
UniProt Q8N608 Q6NXK7
RefSeq (mRNA) NM_001004360 NM_199021
RefSeq (protein) NP_001004360 NP_950186
Location (UCSC) Chr 2:
115.2 – 116.6 Mb
Chr 1:
123.33 – 124.05 Mb
PubMed search [1] [2]

Inactive dipeptidyl peptidase 10 is a protein that in humans is encoded by the DPP10 gene.[1][2][3] Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Function[edit]

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties.[3]

Clinical significance[edit]

Mutations in this gene have been associated with asthma[3] and autism spectrum disorders.[4]

References[edit]

  1. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  2. ^ Qi SY, Riviere PJ, Trojnar J, Junien JL, Akinsanya KO (Jun 2003). "Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases". Biochem J 373 (Pt 1): 179–89. doi:10.1042/BJ20021914. PMC 1223468. PMID 12662155. 
  3. ^ a b c d "Entrez Gene: DPP10 dipeptidyl-peptidase 10". 
  4. ^ Girirajan S, Dennis MY, Baker C, Malig M, Coe BP, Campbell CD, Mark K, Vu TH, Alkan C, Cheng Z, Biesecker LG, Bernier R, Eichler EE (February 2013). "Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder". Am. J. Hum. Genet. 92 (2): 221–37. doi:10.1016/j.ajhg.2012.12.016. PMC 3567267. PMID 23375656. 

Further reading[edit]